Retinal degenerative diseases are one of the important refractory ophthalmic diseases, featured with apoptosis of photoreceptor\ncells. Histone acetylation and deacetylation can regulate chromosome assembly, gene transcription, and posttranslational\nmodification,which are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively.The histone\ndeacetylase inhibitors (HDACis) have the ability to cause hyperacetylation of histone and nonhistone proteins, resulting in a variety\nof effects on cell proliferation, differentiation, anti-inflammation, and anti-apoptosis. Several HDACis have been approved for\nclinical trials to treat cancer. Studies have shown that HDACis have neuroprotective effects in nervous system damage. In this\npaper, we will summarize the neuroprotective effects of common HDACis in retinal degenerative diseases and make a prospect to\nthe applications of HDACis in the treatment of retinal degenerative diseases in the future.
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